Asenapine (Sycrest): sublingual antipsychotic for acute mania
نویسندگان
چکیده
منابع مشابه
New approaches for the management of bipolar disorder: role of sublingual asenapine in the treatment of mania
Bipolar disorder is a prevalent disorder that tends to become progressive without treatment and with inadequate treatment. Second generation (atypical) antipsychotic drugs have increasingly been used as adjunctive treatment or monotherapy for mania, but they have the potential for significant adverse effects and their role in maintenance treatment remains unclear. Asenapine is a new atypical an...
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According to a Medical Letter review of the recently approved atypical antipsychotic asenapine (Saphris), "available data on its efficacy are not impressive." Asenapine is formulated in a sublingual tablet and is approved for acute schizophrenia and manic or mixed bipolar episodes. Its receptor affinity profile is similar to other atypicals. Three placebo-controlled trials have been conducted i...
متن کاملRole of sublingual asenapine in treatment of schizophrenia
Asenapine tablets are a new option for the treatment of schizophrenia. Sublingual administration is essential because bioavailability if ingested is less than 2%. Efficacy is supported by acute and long-term randomized controlled studies conducted by the manufacturer, with asenapine 5 mg twice daily evidencing superiority over placebo in six-week studies of acute schizophrenia, and flexibly-dos...
متن کاملAsenapine: a synthesis of efficacy data in bipolar mania and schizophrenia.
INTRODUCTION This article briefly reviews the efficacy, as well as safety and tolerability, data pertaining to asenapine in bipolar mania and schizophrenia. Postulated mechanism of action is also reviewed. METHODS A PubMed search was conducted using the search term asenapine. All displayed articles were reviewed; we selected for review studies that were part of the regulatory registration pac...
متن کاملAsenapine for bipolar disorder
Asenapine (Saphris(®)) is an atypical antipsychotic drug which has been approved by the US Food and Drug Administration for the treatment of schizophrenia in adults, as well as the treatment of acute manic or mixed episodes of bipolar I in both adult and pediatric populations. Asenapine is a tetracyclic drug with antidopaminergic and antiserotonergic activity with a unique sublingual route of a...
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ژورنال
عنوان ژورنال: Prescriber
سال: 2012
ISSN: 0959-6682
DOI: 10.1002/psb.942